Presents a practical understanding of property fundamentals and structure modification strategies that can be applied to improving drug leads. This title offers a fresh approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related[...]
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to [...]
Deals with the general mechanisms involved in chemical reactions involving enzymes. This book: illustrates the organic mechanism associated with each enzyme-catalyzed reaction; makes the connection between organic reaction mechanisms and enzyme mechanisms; and, compiles the information about molecul[...]
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrap[...]